Earlier AAM was associated with higher estimates of Homeostatic Model Assessment for Insulin Resistance (P for trend .0019) and lower estimates of Single Point Insulin Sensitivity Estimator (P for trend <.0001) and Quantitative Insulin-sensitivity Check Index (P for trend .0134) with adjustment for age, race/ethnicity, education, parity, menopause status, menopause-related hormone therapy, family history of diabetes, smoking status, physical activity, alcohol, and BMI (Supplementary Table S3) (33). The gene discussed is INS; the disease is diabetes mellitus.