CD8A and neoplasm: Using this approach, Figure 2A shows 3 types of tumor immune microenvironments including (a) increased CD8+ T cell penetration into the tumor core in COX2lo tumors (Hot-Inflamed), (b) CD8+ T cells that were spatially restricted to tumor stroma in COX2hi tumors (Cold-Excluded), and (c) the sparse distribution or absence of CD8+ T cells in the tumor epithelium in COX2hi tumors (Cold-Immune Desert).