Whole tumor RNA-Seq revealed important changes beginning as early as day 3 after IR that persisted throughout the experiments, showing that 6 Gy + INDO treatment supports increased cGAS/STING signaling and augmented type I IFN expression including IFN-αβ, IFN-β1, IFN-α4, and IFN-α13 as well as increased IRF3 and type I IFN receptors IFNAR1/2 (Figure 6 and Supplemental Figure 8). This evidence concerns the gene CGAS and neoplasm.