CD8A and neoplasm: Given that type I IFN signatures were associated with CD8+ T cell penetration into the tumor core while cholesterol signatures were associated with the restriction of CD8+ T cells in tumor stroma, these observations implicate a key role of the spatial configuration of CD8+ T cells during polarization of the tumor immune microenvironment that was further validated in a cohort of 579 patients with TNBC (2).