When implanted into syngeneic immunocompetent hosts, T cell–inflamed tumor cell clones give rise to tumors characterized by an immunogenic TME containing CD4+ and CD8+ T cells and a paucity of granulocytic myeloid–derived suppressor cells (gMDSCs), while non–T cell–inflamed clones give rise to tumors characterized by a paucity of T cells and an abundance of gMDSCs (40). The gene discussed is CD4; the disease is neoplasm.