The release of sTREM2 from its membrane-bound precursor is influenced by various stimuli, including LPS, interleukin-1β (IL-1β), oligomeric Aβ, Vascular Endothelial Growth Factor (VEGF), viral infections like HIV, and cytokines such as IL-13 and IL-4, which promote sTREM2 secretion (Wu et al., 2015; Gisslén et al., 2019; Zhong et al., 2019; Vilalta et al., 2021). Here, VEGFA is linked to viral infectious disease.