Moreover, alterations in peripheral sTREM2-related inflammatory markers such as Fibroblast Growth Factor 2 (FGF-2), Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF), and IL-1β significantly correlate with stages of AD, reflecting sTREM2 levels (Weber et al., 2022). This evidence concerns the gene FGF2 and Alzheimer disease.