The important genes associated with lissencephaly are LIS1 on the short arm of chromosome 17, XLIS located on the long arm of chromosome X, and TUBA1A gene as a third genetic cause of lissencephaly [10,11]. Recently, a mutation in TUBG1 has been seen associated with it [9]. MCDs caused by genetic mutations affecting the function of microtubules are together called tubulinopathies [12]. The gene discussed is PAFAH1B1; the disease is lissencephaly spectrum disorders.