VEGFA and polyneuropathy: Indeed, the diagnostic criteria of POEMS syndrome were fulfilled with two mandatory major criteria (polyneuropathy, monoclonal plasma cell-proliferative disorder, which was lambda light-chain restricted); two major criteria (sclerotic bone lesions and VEGF elevation); and three minor criteria (extravascular volume overload as peripheral edema and ascites, endocrinopathy as hypogonadotropic hypogonadism and skin changes as acrocyanosis and hypertrichosis) (Table 1).