Indeed, the diagnostic criteria of POEMS syndrome were fulfilled with two mandatory major criteria (polyneuropathy, monoclonal plasma cell-proliferative disorder, which was lambda light-chain restricted); two major criteria (sclerotic bone lesions and VEGF elevation); and three minor criteria (extravascular volume overload as peripheral edema and ascites, endocrinopathy as hypogonadotropic hypogonadism and skin changes as acrocyanosis and hypertrichosis) (Table 1). This evidence concerns the gene VEGFA and endocrine system disorder.