VEGFA and POEMS syndrome: LD, an immunomodulatory drug derivative of thalidomide, is an interesting option in POEMS syndrome due to its lack of neurologic toxicity, its effectiveness against plasma cell proliferations and its anti-VEGF effect. To minimize the prothrombotic effect of LD, rivaroxaban and clopidogrel were maintained during the period of the administration of this molecule. LD resulted in rapid neurological and systemic improvement in our patient, similar to previous reports [13,14].