Some targets reflected higher degrees of involvement, including mitogen-activated protein kinase (MAPK), epidermal growth factor receptor (EGFR), PI3KCA, Mcl-1, vascular endothelial growth factor (VEGF), and peroxisome proliferator-activated receptor gamma (PPAR γ), etc. These protein targets may account for the mitochondrial actions of GYPs in treating HF. Here, WNK2 is linked to hydrops fetalis.