Figure 8B shows that circulating monocytes were significantly upregulated in sepsis patients compared to critical controls, whereas mast cells resting and T cells CD8 were significantly downregulated compared to critical controls. Correlations between immune cells and five key genes were assessed in patients with sepsis, revealing that plasma cells, macrophages M0, monocytes, T cells regulatory (Tregs), eosinophils and NK cells resting were simultaneously and significantly associated with more than two key genes (Fig. 8C). This evidence concerns the gene CD8A and Sepsis.