The deficiency or dysfunction of catalase is thought to be associated with the pathogenesis of many age-related degenerative diseases, such as diabetes, hypertension, AD, Parkinson’s disease, bipolar disorder, schizophrenia, and cancer (Al-Abrash, Al-Quobaili & Al-Akhras, 2000; Jimenez-Fernandez et al., 2022; Lane, Wang & Lin, 2023). Here, CAT is linked to bipolar disorder.