On the one side, increased EZH2 levels in NSCLC produced by HIF-1a can suppress F-box/leucine-rich repeat protein 7 (FBXL7), an E3 ubiquitin ligase responsible for 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 (PFKFB4) degradation. The gene discussed is FBXL7; the disease is non-small cell lung carcinoma.