NLRP3 and Alzheimer disease: A recent in vitro study showed that 5 μMsulforaphane inhibitedthe NLRP3 inflammasome activation in LPS and ATP-induced N9 microglialcells.9 Moreover, NLRP3 inhibition in microglialcells with a small molecule MCC950 resulted in reduced Aβ pathology,suggesting that reduced NLRP3 activity may be ameliorative in AD treatment.10