Among them, enhanced fibrinogen alpha chain (FIBA) levels in late CRC stages and their association with distant metastasis were previously reported.25 Also, increased alpha-1-acid glycoprotein 2 (A1AG2) was linked to shorter survival rates in a CRC cohort.26 Similar to the previous comparison, the regression analysis showed that only were 4 DEPs (Figure 5B, Supplemental Table S8). Here, ORM2 is linked to colorectal carcinoma.