Among the differentially expressed proteins (DEPs), inter-alpha-trypsin inhibitor heavy chain (ITIH)3, leucine-rich alpha-2-glycoprotein (A2GL), C9, and lipopolysaccharide-binding protein (LBP) showed the highest levels in CRC patients, while apolipoprotein (APO) A4, acid labile subunit (ALS), and kallikrein B1 (KLKB1) showed the lowest levels compared to healthy controls. The gene discussed is ITIH3; the disease is colorectal carcinoma.