Noteworthy, SERPINA4 is an anti-angiogenic and anti-inflammatory agent that was decreased in CRC patients versus healthy volunteers and its downregulation was common in inflammatory processes as well as in cancer.24 Additionally, C8A and immunoglobulin heavy constant gamma 2 (IGHG2) may be related to cancer-associated inflammation thus promoting an exacerbated immune response in these patients. The gene discussed is IGHG2; the disease is cancer.