Cox regression analyses demonstrated that pretreatment blood albumin (p=0.003, HR 1.72, 95% CI: (1.21, 2.45)) and derived neutrophil to lymphocyte ratio (dNLR) (p=0.003, HR 1.71, 95% CI: (1.20–2.44)) were independent predictors for OS in SCLC patients. The gene discussed is ALB; the disease is small cell lung carcinoma.