Common grade 3–4 AEs for patients undergoing IC+A versus IC-A treatment were as follows: anemia (25.6% vs 18.5%, P = 0.252), neutropenia (23.0% vs 14.8%, P = 0.194), thrombocytopenia (12.8% vs 6.1%, P = 0.187), and ALT elevation (5.1% vs 6.1%, P = 0.59). This evidence concerns the gene GPT and Decreased total neutrophil count.