A comparative study recently has examined genes of cytotoxic molecules shared by cytotoxic Tfh cells and CD4+CTLs in IgG4-RD, including CRTAM, SLAMF7, NKG7, GZMA, GZMK, CCL4 and CCL5 (78). The gene discussed is CD4; the disease is immunoglobulin G4-related sclerosing disease.