has shown that LILRB1 but not LILRB2 is highly expressed in various subsets of tumor associated macrophages from human patients and interacts with MHC1 molecules, thereby exerting its inhibitory function on macrophage activity (23).This finding holds significant implications for understanding the immunoregulatory mechanisms of macrophages and developing more effective strategies for cancer immunotherapy. The gene discussed is LILRB1; the disease is cancer.