SQSTM1 and Miyoshi myopathy: Interestingly, here, we found that TLR signaling in MM cells can potentially reduce the sensitivity to PI inhibitors by several of these mechanisms we observed: 1) increased expression of proteasomal components, 2) increased expression of the autophagy cargo receptor SQSTM1, 3) increased expression of pro-survival BCL2-family members, and 4) increased basal glycolysis and OXPHOS.