The release of these pro-inflammatory substances induces the recruitment of monocytes, neutrophils, and macrophages into the infected tissue, which in turn secrete IL-6, IL-1β, IL-8, TNF-α (181, 185), generating a concentrated medium of Reactive Oxygen Substances (ROS), which contribute to viral pathogenesis and by producing damage in the tissue surrounding the infection (185). This evidence concerns the gene IL6 and infection.