PVALB and myeloid sarcoma: In particular, this treatment selectively rescued GABAergic transmission alterations typical of the EAE striatum, likely due to reduced local inflammatory reaction and increased survival of parvalbumin-positive GABAergic interneurons, which are highly sensitive to EAE and MS processes (32, 33).We also demonstrated that ozanimod, a S1PR 1,5 modulator approved for the treatment of RRMS, was able to dampen striatal glutamatergic alterations in EAE mice as well as in EAE T lymphocytes homologous chimeric ex-vivo model (8).