CDH17 and polyp of large intestine: Furthermore, given the high expression of CDH17 in CRC tumors and the good imaging capability of E8-IR800CW against CDH17, fluorescent endoscopy combined with E8-IR800CW could be clinically utilized to image CDH17-positive CRCs and could potentially differentiate the tumors from healthy tissues, which might facilitate the CRC removal with endoscopic surgery, which has been widely applied for colorectal polyps [48].