CDH17 and colorectal carcinoma: Collectively, these results about E8-PE38 immunotoxin in CRC cells indicate that CDH17 Nb E8 could enhance the inhibitory effect of PE38 on CRC cells through CDH17-mediated internalization, and E8-PE38 immunotoxin can induce CRC cell apoptosis through the complicated influence on intracellular signal networks, suggesting the great potential for E8-PE38 immunotoxin in the treatment of CRC in vivo.