CEACAM5 and colorectal carcinoma: In terms of surgery navigation for CRC, several targeted NIR probes have been developed for imaging and imaging-guided surgery, including carcinoembryonic antigen (CEA) antibodies conjugated with fluorophore BM-104 (SGM-101), IRDye800CW (IR800CW) or isotope 111In, integrin targeting peptide cRGD [cyclo-(RGDyK)] modified with ZW800-1, VEGFA (vascular endothelial growth factor A) antibody bevacizumab labeled with IR800CW, or pH-activatable probe ONM-100.