In terms of microglial phenotype, exercise can regulate CD68+ (Ziegler-Waldkirch et al., 2018; Zhang S. et al., 2022; Oroszi et al., 2023; Wang Y. et al., 2023), CD86+ (Lu et al., 2017; Zhang et al., 2019; Feng et al., 2023; Yang et al., 2023), triggering receptor expressed on myeloid cells 2 (TREM2) (Zhang L. et al., 2022) and inflammatory molecules (Xu et al., 2016, 2018; Nakanishi et al., 2021; Han et al., 2023) in AD rodent models. The gene discussed is TREM2; the disease is Alzheimer disease.