APP and Alzheimer disease: Nonetheless, there are some reports that physical exercise is ineffective in regulating AD pathology in 5XFAD, APP/PS1, and Tg2576 mouse models, all characterized by the presence of plaques in the absence of tau pathology (Nichol et al., 2008; Xu et al., 2013; Zhang J. et al., 2018; Belaya et al., 2020; Svensson et al., 2020).