PSEN2 and Alzheimer disease: AD animal models commonly utilize mutations in genes related to amyloid beta [amyloid protein precursor (APP), presenilin-1 (PSEN1), presenilin-2 (PSEN2)] and tau [microtubule-associated protein tau (MAPT)] processing, which lead to the formation of plaques and neurofibrillary tangles (Sanchez-Varo et al., 2022; Yokoyama et al., 2022).