Previous studies have indicated that the lncRNA TRPM2-AS/miR-15b-5p/PPM1D axis can promote malignant tumors in osteosarcoma cells 45 or Linc00662 can act as a sponge for miR-15b-5p, facilitating the progression of osteoarthritis 46. This evidence concerns the gene PPM1D and osteosarcoma.