To better characterise the correlation between immune cells and the MMP score, we examined the specific correlation between each TME-infiltrating cell type and the MMP score using Spearman correlation analysis, which showed a strong correlation of the majority in Figure 3A. Our study showed that TME immune cell infiltration was significantly increased in tumour with high MMP scores, showing a significant positive correlation with follicular helper T cells, CD4 memory activated, naive B cells, and activated dendritic cells (Figure 3B, C). Here, CD4 is linked to neoplasm.