Previous studies have shown that TXNDC12 is highly expressed in a variety of tumors 19-21, so we first analysed the expression of TXNDC12 in pan-cancer and the results showed that TXNDC12 expression levels were up-regulated in tissues of most cancer types, including PAAD, compared to normal tissues (Fig. 1A). This evidence concerns the gene TXNDC12 and pancreatic adenocarcinoma.