Furthermore, in order to investigate the effects of overexpression of GGT7 in combination with knockdown of TXNDC12 on GSH content as well as ferroptosis in PAAD cells, the authors performed GSH, MDA, and ROS content measurements, and the results showed that overexpression of GGT7 could partially reverse the knockdown of the inhibitory effect of TXNDC12 on GSH and the promotional effect on MDA, ROS compared to si TXNDC12-2 group (Fig. 9B-D). This evidence concerns the gene TXNDC12 and pancreatic adenocarcinoma.