TXNDC12 and cancer: In addition, several studies have confirmed that TXNDC12 also played an important role in cancer development and progression 15, 16, such as TXNDC12 promoted cell growth, migration, and invasion promoting tumorigenicity in human gastric cancer via FAK/ERK signaling pathway 17, TXNDC12 also promoted nuclear translocation of β-catenin promoting epithelial-mesenchymal transition process to promote metastasis and invasion of hepatocellular carcinoma 18.