Recent investigations into the role of TBX3 in various sarcomas have revealed that TBX3 may be triggered by c-Myc transcription to promote the transformation of human mesenchymal stem cells into sarcomas, leading to enhanced proliferation, migration, and invasion of chondrosarcoma, liposarcoma, and rhabdomyosarcoma. The gene discussed is TBX3; the disease is liposarcoma.