IL6 and cancer: The hallmark enrichment analysis results demonstrated a significant enrichment of cancer-related gene sets, including IL6 (Interleukin 6)/JAK (Janus Kinase)/STAT3 (Signal Transducer and Activator of Transcription 3) signaling, Inflammatory response, Tumor Necrosis Factor-alpha (TNF-α) signaling via Nuclear Factor kappa-light-chain-enhancer of activated B cells (NF-kB), complement, hedgehog signaling, coagulation, KRAS signaling up, IL2/STAT5 signaling and allograft rejection the in the SPRGS-high subtype (Figure 2F).