Moreover, other laboratories disclosed 5 key VMTRGs (CNIH1, KIF20A, GALNT2, GRIA1, and AP3S1), 13 key VMTRGs (FOXD1, NXPH4, ADAD2, COX8C, C8G, CREG2, MUCL3, PSCA, NTF4, LRP2, INSL4, UGT2B4, and PLA2G2F) and 4 VMTRGs (GDI1, LMANL2, KLC3, and LRP2) as prognostic signatures for LUAD and CRC 6, 35, 36. The gene discussed is COX8C; the disease is colorectal carcinoma.