While the expression of Kv8.1 and Kv2.2 have not been reported to be altered in SOD(A4V) transgenic mice, KCNV1/Kv8.1 is reduced in the motor cortex of sporadic amyotrophic lateral sclerosis patients.2 This evidence concerns the gene KCNV1 and sporadic amyotrophic lateral sclerosis.