Our study demonstrated that EALD extract could improve renal damage inhibition by reducing both ERS and inflammation in rat kidney and cell culture models; natural compounds such as certain polyphenols have been able to attenuate the protein expression involved in UPR signaling, such as PERK-ATF4-CHOP, BiP/GRP78, and IRE1-XBP1, and consequently ER stress-related apoptosis in various renal disorders, numerous studies have indicated the effective and beneficial role of apigenin in modulating renal injury accompanied by ERS (72, 73). This evidence concerns the gene ATF4 and kidney disorder.