On the contrary, other investigations have revealed that fucosylation activates death receptor 5 in colon cancer cells (57), and loss of a1,6-fucosyltransferase inhibits liver regeneration, while L-fucose, which can enhance GDP-fucose production through a salvage pathway, significantly promotes the delayed liver regeneration (58). This evidence concerns the gene TNFRSF10B and malignant colon neoplasm.