PLOD1 and Hirsutism: Flutamide treatment reduces hirsutism (13, 14) and decreases plasma levels of LH, proportional level of LH/FSH, androgens, triglycerides, and LDL levels in young girls and women with hyperinsulinemic hyperandrogenemia or PCOS (15-17), but its effects in restoring ovulatory cycles and menstruation in anovulatory PCOS patients is a matter of debate (16, 17).