Similarly, a study (64) showed that administration of OLR at a dose of 500 mg/kg daily alleviates gastric damage and ulceration by the decrease of inflammation as tumor TNF-α, prostaglandin E2, endothelial nitric oxide synthase, and caspase-3 levels in indomethacin-induced gastric ulcer rat. The gene discussed is NOS3; the disease is gastric ulcer.