Their major function appears to be associated with histone methylation and to a further extent chromatin remodelling and subsequent downstream gene expression.1 The SMYD family plays an intrinsic role in both normal and diseased states, with overexpression of SMYD2 found in cancerous tumours specifically oesophageal, bladder, and stomach whilst SMYD3 overexpression is detected in liver, colon, and breast carcinomas.2 However, the complete and categorical understanding of the role of SMYD3 in cancer has yet to be fully understood.3 This evidence concerns the gene SMYD3 and cancer.