TNF and cancer: Inflammatory cells and their inflammatory mediators, such as cytokines (i.e., tumor-necrosis factor-α [TNF-α], interleukin-6 [IL-6], transforming growth factor-β, and IL-10), chemokines (CC chemokine receptors), lipid mediators (PGs and leukotrienes), inducible nitric oxide synthase, nuclear factor kappa-light-chain-enhancer of activated B-cells, hypoxia-inducible factor 1-alpha, and signal transducer and activator of transcription 3, are the main molecules simultaneously involved in inflammation and cancer [24, 25].