While the Noonan syndrome associated KrasV14l exhibits attenuated biochemical activation compared to common cancer associated KRAS alleles (Schubbert et al., 2007), strong activation was shown for Ptpn11D61Y, which is frequently linked to juvenile myelomonocytic leukemia (JMML) in patients (Chan et al., 2009). Here, KRAS is linked to Noonan syndrome.