PTPN11 and RASopathy: As the RASopathy model, we used mice heterozygous for the floxed mutation Ptpn11D61Y or KrasV14l as well as for the Emx1-cre allele and as the control, their littermates homozygous for the Ptpn11 or Kras wild-type allele and heterozygous for the Emx1-cre allele.