APOE and atherosclerosis: Similarly, tanshinone IIA has also been shown to suppress the activated NLRP3 inflammasomes in high-fat diet fed ApoE−/− mice (Wen et al., 2021), and inhibit the secretion of inflammatory mediators like C-reactive protein, TNF-α, oxidized low-density lipoprotein as well as IL-1β in serum of apolipoprotein E knockout mice (Xuan et al., 2017), thereby alleviating processes of atherosclerosis.