In addition, Li et al. (2021) have found that inflammatory lesion of the high-fat diet treated ApoE−/− mouse are triggered by Gal-3 activation of the NLRP3 inflammasomes, which serves as a potential site for quercetins that exerts advantageous anti-atherogenic actions, whereas indicating an potential path for preventing and treating atherosclerosis by natural-derived quercetins. Here, NLRP3 is linked to atherosclerosis.