Furthermore, FIP200 silencing with an siRNA oligo was reported to promote cell cycle progression and reduce cell death in LNCaP, suggesting a tumour suppressive function of autophagy in these cells, in concordance with the observed increased biochemical recurrence in prostate cancer patients who had undetectable FIP200 protein expression in their tumours (Li et al., 2014). This evidence concerns the gene RB1CC1 and Familial prostate cancer.