In contrast to the two studies mentioned above, another report proposed that autophagy contributes to radioresistance in prostate cancer cells, since siRNA-mediated knockdown of LC3A or LAMP2A aggravated the detrimental effects of radiation on cell viability in PC3 and DU145 cells (Koukourakis et al., 2015). The gene discussed is MAP1LC3A; the disease is Familial prostate cancer.