In contrast to the two studies mentioned above, another report proposed that autophagy contributes to radioresistance in prostate cancer cells, since siRNA-mediated knockdown of LC3A or LAMP2A aggravated the detrimental effects of radiation on cell viability in PC3 and DU145 cells (Koukourakis et al., 2015). This evidence concerns the gene MAP1LC3A and prostate carcinoma.