This event is accompanied by the early activation of inflammatory pathways via activation of nuclear factor-κB (NF-κB) and its downstream inflammatory mediators (e.g., tumor necrosis factor- α (TNF-α) and IL-6), which represent a main event in AP pathogenesis (Ohmuraya and Yamamura, 2008). Here, NFKB1 is linked to alkaline phosphatase measurement.