Notably, multiple inflammatory mediators, i.e., IL-17, IL-6 and IL-10 as well as IL-12 and IL-15 have been shown to play a main role in the pathogenesis of pancreatitis, and their serum levels have been reported to correlate with disease severity in AP patients (Pezzilli et al., 1999; Kamei et al., 2010; Li et al., 2021). This evidence concerns the gene IL10 and pancreatitis.