CFH and Genetic thrombotic microangiopathy: While most of the pediatric age group patients present with diarrhea-associated HUS, here we discuss a case of an 11-year-old female who presented with hematuria and vomiting and was then extensively worked up for all possible causes of hemolysis which included thrombotic microangiopathy (TMA) panel and unexpectedly anti-factor H autoantibody came positive.