HDAC8 and Cornelia de Lange syndrome: The common features of CdLS5 similar to typical CdLS are postnatal growth retardation, microcephaly, developmental delay, facial dysmorphism including hooding of eyelids, arched eyebrows, depressed nasal bridge, micrognathia, cleft palate, long philtrum, gastroesophageal reflux disease (GERD), congenital heart disease, limb defects (more in upper limbs), and genitourinary abnormalities [2,6-9].