Interleukin 17 (IL-17) is a key mediator of PsO and PsA, and Helper T-cell polarization towards Th17 plays an important role in the immunopathogenesis of disease. However, the role of IL-17, particularly IL-17A, in modulating cardiovascular disease is less well-known. In mouse models, the blockade of IL-17A reduces atherosclerotic plaque burden, inflammatory cell infiltration, cytokine/chemokine induction, and lesion development [7-11]. Here, IL17A is linked to cardiovascular disorder.