CCNE1 and ovarian cancer: Additionally, ovarian cancers have been associated with many gene mutations and aberrant protein expression including but not limited to p53, p21, cyclin E1, Rsf-1, laminin γ1 protein, fatty acid synthase, stathmin1, p16, and BRCA [3]. BRCA1 and BRCA2 have many functions including producing proteins that repair damaged DNA and regulate the cell cycle.