MKI67 and neoplasm: The immunohistochemical results demonstrated that Ki67 expression in tumor tissues of the Oxa + BHB group was prominently lower than that of the Oxa alone, whereas cleaved-caspase3 expression was significantly upregulated (Fig. 2F), indicating that consistent with the results of in vitro experiments, BHB intervention enhanced the sensitivity of CRC cells to Oxa.