FZD6 and glioblastoma: A previous study also showed that ectopic FZD6 expression can induce cell proliferation and sphere formation in proneural glioblastoma.28Fzd6 regulates both canonical and non-canonical WNT pathways,28,29 and here we found it can affect β-catenin during tooth root development, but whether this is a direct or indirect effect still remains to be explored in the future.