In addition, FERMT2 upregulates TGFBR1 expression, forming a positive feedback loop with the TGF-β signaling pathway.23 Furthermore, FERMT2 exerts a pro-cancer effect by promoting cytokine secretion in PSCs.24 In this study, analysis of pancreatic cancer single-cell sequencing data and FERMT2 IHC staining of tissue protein microarrays demonstrated that FERMT2 was predominantly expressed in pancreatic CAFs in pancreatic cancer tissues. Here, FERMT2 is linked to familial pancreatic carcinoma.