Consistent with the findings in subcutaneous tumor implantation and PDX models, Masson’s staining revealed that the collagen content of the mice treated with IEVs-PFD/138 was found to be comparatively lower than that of the mice treated with PBS and GEM, suggesting the inactivation of CAFs and the inhibition of collagen secretion (Fig. 8m). This evidence concerns the gene TBX1 and neoplasm.