Furthermore, BMSCs are one of the potential sources of CAFs.6 During tumor development, BMSCs can be recruited to the TME and differentiate into CAFs.7 Due to their homing ability, BMSC-derived EVs (BMSC-EVs) possess both the inherent advantages of EVs and the characteristics associated with BMSCs, making them a highly promising therapeutic approach for selectively targeting CAFs in pancreatic cancer. Here, TBX1 is linked to neoplasm.