CD27 and neoplasm: After adjustment for other covariates included in the multivariate COX regression analysis, a high expression level of CD27 (HR = 0.566, 95% CI:0.418–0.766, P < 0.001) and chemotherapy (HR = 0.341, 95% CI:0.203–0.571, P < 0.001) were independent protective factors for survival, and Tumor_residual_disease: 1–10 mm (HR = 1.743, 95% CI:1.067–2.848, P = 0.026) or Tumor_residual_disease: 10 mm~ (HR = 2.296, 95% CI:1.359–3.879, P = 0.002) were independent risk factors (Fig. 2D).