Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a member of the tumor necrosis factor (TNF) family of death ligands, and it binds to death receptor 4/5 (DR4/5) to selectively initiate caspase-8 (CASP 8)-dependent extrinsic apoptosis in tumor cells without affecting normal cells [8, 9]. The gene discussed is TNFRSF10A; the disease is neoplasm.