CASP3 and acute myeloid leukemia: TP53INP2 overexpression increased the sensitivity of AML cells to TRAIL, decreasing cell viability (Fig. 3g), reducing the number of colonies (Fig. 3h), increasing the number of apoptotic cells (Fig. 3i) and increasing the levels of cleaved CASP 8 and cleaved CASP 3 (Fig. 3j).