NPM1 and acute myeloid leukemia: Herein, we demonstrated that AML cells with high TP53INP2 expression were more sensitive to TRAIL and that cytoplasmic TP53INP2 modulated by mutant NPM1 functioned as a scaffold linking the ubiquitin ligase TRAF6 and CASP 8 to promote the ubiquitination and activation of CASP 8.