Given our earlier findings that the E3 ubiquitin ligase TRAF6 mediates the K63 ubiquitination of ULK1 in leukemia cells [37] and the results of MEGA analysis in this work showing a TRAF6-interacting motif in the TP53INP2 protein, we analyzed the potential regulatory effect of TRAF6 on CASP 8 ubiquitination in the presence of TP53INP2. The gene discussed is ULK1; the disease is leukemia.