In particular, loss-of-function mutations in the paternally expressed imprinted genes makorin ring finger 3 (MKRN3) and delta-like 1 homolog (DLK1) have been shown to cause central precocious puberty, suggesting the important role of imprinted genes in regulating puberty timing [15–18]. The gene discussed is MKRN3; the disease is central precocious puberty.