According to the literature, DLK1 plays an inhibitory role in the regulation of puberty, as its deficiency has been associated with a CPP phenotype in both non-syndromic (mutation with loss of function) [18] and syndromic conditions, such as Temple syndrome, due to altered methylation on chromosome 14q32, where the gene is mapped. This evidence concerns the gene DLK1 and central precocious puberty.