Further, CC chemokine ligand (CCL) 4, CXCL1, and granulocyte-colony stimulating factor (G-CSF) levels were significantly increased in 3xTg-AD males at 15 months of age and trended upward in 3xTg-AD females, nearing statistical significance between 21 and 24 months of age. The gene discussed is CSF3; the disease is Alzheimer disease.