IL6 and Alzheimer disease: We found that levels of interleukin (IL)-12, IL-10, IL-6, and CXC chemokine ligand (CXCL) 2 were significantly increased in 3xTg-AD males only, at 18 months of age, while CXCL9 and CXCL10 levels were significantly increased in 3xTg-AD females only, at 24 months of age (see Supplementary Fig. 1, Additional file 4).