MAPT and Alzheimer disease: Alzheimer’s disease, the most common form of dementia, is a progressive neurodegenerative disorder characterized pathologically by amyloid beta (Aβ) plaques, neurofibrillary tangles (NFTs) and neuropil threads comprised of hyperphosphorylated tau, gliosis and neuroinflammation, as well as neuronal and synaptic loss [1, 2].