CD4 and Alzheimer disease: Marchese et al. and Kapadia et al. have provided strong evidence that 3xTg-AD mice display manifestations of systemic autoimmunity, including splenomegaly, hepatomegaly, elevated serum autoantibodies, reduced hematocrit, and elevated double-negative (CD4-/CD8-) T splenocytes, which are all exacerbated in 3xTg-AD males [26, 27].