With the objective of elucidating the mechanisms by which CodY influences GBS virulence and considering the important contribution of interactions with plasma and ECM proteins to the infection process, in the present study we compared the adhesive properties of a codY-null and wild-type ST-17 strain (BM110) to fibronectin and fibrinogen and investigated the role played by Srr2 in such interactions. Here, FN1 is linked to infection.