The Fn binding proteins identified in GBS so far include: (i) the streptococcal C5a peptidase B (ScpB), which is able to interact with adsorbed Fn [37], (ii) the streptococcal Fn binding protein A (SfbA), which facilitates the invasion of GBS into human brain microvascular endothelial cells (hBMECs) in vitro and contributes to meningitis development in vivo [38], and (iii) the GBS bacterial surface adhesin (BsaB), that promotes GBS attachment to epithelial vaginal ME-180 cells [39]. Here, FN1 is linked to meningitis.